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HeLa cells normally Convey low levels of endogenous Atl1 and plentiful amounts of Atl2 and Atl349. siRNA-mediated knockdown of Atl2 or Atl3 ends in a normal ER morphology by fluorescence microscopy with a small subset of double knockdown cells demonstrating additional tubular, fewer reticular ER. probably the most pronounced outcome of atlastin red